Left ventricle myocardial remodeling following septal myectomy in patients with hypertrophic obstructive cardiomyopathy.

ABSTRACT:

Background

Left ventricular (LV) reverse myocardial remodeling occurs following septal myectomy in hypertrophic obstructive cardiomyopathy (HOCM), but it remains unclear whether diffuse fibrosis is reversible during this period. Extracellular volume fraction (ECV) and indexed extracellular volume (iECV) are important surrogate markers of diffuse myocardial fibrosis. This study aimed to investigate whether diffuse myocardial fibrosis in HOCM can regress after myectomy.

Methods

A prospective cohort study was conducted among patients with HOCM. All subjects underwent clinical assessment (clinical history, 6-min walk test, biochemical analysis), echocardiography, and cardiovascular magnetic resonance preoperatively and 6months after septal myectomy.

Results

A total of 43

SUBMITTER: Lu G 

PROVIDER: S-EPMC12022643 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature