A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population.

ABSTRACT:

Background

Angiotensin-converting enzyme inhibitor-induced angioedema (AE-ACEI) is a life-threatening adverse event; globally, it is the most common cause of emergency presentations with angioedema. Several genome-wide association studies (GWASs) have found genomic associations with AE-ACEI. However, despite African Americans having a 5-fold increased risk of AE-ACEI, there are no published GWASs from Africa.

Objective

The aim of this study was to conduct a GWAS of AE-ACEI in a South African population and perform a meta-analysis with an African American and European American population.

Methods

The GWAS included 202 South African adults with a history of AE-ACEI and 513 controls without angioedema following angiotensin-converting enzyme inhibitor (ACEI) treatment for

SUBMITTER: Mugo JW 

PROVIDER: S-EPMC12022653 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature