The Associations Between Gallstone Disease and Pan-Cancer Incidence Risk Based on Over 13 Million Participants.

ABSTRACT:

Background

Increasing evidence connects gallstone disease (GSD) to all types of cancer incidence; however, the results were inconsistent. The present study aimed to evaluate whether and to what extent these associations exist comprehensively.

Methods

We systematically searched published longitudinal studies indexed in PubMed and Embase database from dates of inception to March 31, 2020. We pooled the effect of GSD on all-cause cancer incidence. Moreover, we further employed stratified analysis concerning sex, geographic background, surgery status, and follow-up period. Trial sequential analysis (TSA) was applied to decide whether the included sample size was sufficient for evaluating these associations.

Results

Fifty-one studies incorporating over 13 million participa

SUBMITTER: Yu W 

PROVIDER: S-EPMC12022677 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature