Association of Age-Related Macular Degeneration with Cholelithiasis.

ABSTRACT:

Purpose

Dysregulated lipid metabolism likely contributes to the pathogenesis of age-related macular degeneration (AMD). There is an overlap in risk factors between AMD and diseases of lipid metabolism, such as cholelithiasis, suggesting that an association between these diseases could provide insight into AMD pathogenesis. This study sought to determine if there is an association between cholelithiasis and AMD.

Design

A cohort study was conducted using patients in the Optum deidentified Clinformatics Data Mart database from January 1, 2000, to June 30, 2022.

Participants

Patients over the age of 55 with ≥2 years of data and no prior history of AMD were included. The exposed cohort included patients who had a history of cholelithiasis, cholecystitis, or cholecystectomy

SUBMITTER: Zhang KR 

PROVIDER: S-EPMC12022688 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature