Mesenteric benign lymph node enlargement in colorectal cancer: Friend or foe?

ABSTRACT:

Introduction

Benign lymph node enlargement (BLNE) is common in colorectal cancer; however, few studies have investigated its influence on prognosis, clinicopathological features, and pathogenesis.

Methods

A cohort study was conducted to analyze the clinicopathologic features and prognosis of colorectal cancer patients, categorized based on the presence or absence of BLNE. Given the correlation between lymph nodes and immune response, immunohistochemistry, transcriptome analysis, and exon sequencing were employed to further investigate the differences in the immune microenvironment of primary tumors.

Results

Overall, 630 AJCC stage I/II patients were included in the study, with 131 in the BLNE group and 499 in the Non-BLNE (NBLNE) group. Patients in the BLNE group were

SUBMITTER: Junwei W 

PROVIDER: S-EPMC12022693 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature