Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial.

ABSTRACT:

Importance

Preclinical and preliminary human evidence suggests that metformin, a first-line treatment for type 2 diabetes, reduces inflammation, preserves cartilage, and improves knee pain in knee osteoarthritis.

Objective

To evaluate the effects of metformin on knee pain at 6 months in participants with symptomatic knee osteoarthritis and overweight or obesity.

Design, setting, and participants

Community-based randomized, parallel-group, double-blind, placebo-controlled clinical trial that used telemedicine to recruit and follow up participants remotely. Individuals with knee pain for 6 months or longer, a pain score greater than 40 mm on a 100-mm visual analog scale (VAS), and body mass index of 25 or higher were recruited from the community through local and social

SUBMITTER: Pan F 

PROVIDER: S-EPMC12022862 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature