Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.

ABSTRACT:

Introduction

Sex differences are apparent in neurodegenerative diseases but have not been comprehensively characterized in frontotemporal dementia (FTD).

Methods

Participants included 337 adults with autosomal dominant FTD enrolled in the ALLFTD Consortium. Clinical assessments and plasma were collected annually for up to 6 years. Linear mixed-effects models investigated how sex and disease stage are associated with longitudinal trajectories of cognition, function, and neurofilament light chain (NfL).

Results

While sex differences were not apparent at asymptomatic stages, females showed more rapid declines across all outcomes in symptomatic stages compared to males. In asymptomatic participants, the association between baseline NfL and clinical trajectories was weaker

SUBMITTER: Memel M 

PROVIDER: S-EPMC12022891 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature