Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.

ABSTRACT:

Introduction

Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences in phenotypes between genetic and sporadic bvFTD females resulting in underdiagnosis of sporadic bvFTD females.

Methods

We included genetic and sporadic bvFTD patients from two multicenter cohorts. We compared behavioral and cognitive symptoms, and gray matter volumes, between genetic and sporadic cases in each sex.

Results

Females with sporadic bvFTD showed worse compulsive behavior (p = 0.026) and language impairments (p = 0.024) compared to females with genetic bvFTD (n = 152). Genetic bvFTD females had smaller gray matter volumes than sporadic bvFTD females, particularly in the parietal lobe.

Discussion

Females wi

SUBMITTER: Liu X 

PROVIDER: S-EPMC12022892 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature