Sex differences in the executive and behavioral reserve of autosomal dominant frontotemporal dementia.

ABSTRACT:

Introduction

Self-reported sex influences brain resilience, but its role in genetic frontotemporal dementia (FTD) remains unclear.

Methods

We analyzed 394 genetic-FTD patients and 279 controls from the ALLFTD consortium, assessing annual neuropsychological performance and MRI-based cortical thickness. Clinical characteristics and cortical thickness were compared between sexes. We used the residuals of linear regression models, which predict each participant's cognitive and behavioral performance levels relative to cortical thickness, as a proxy for reserve. We then modeled sex differences in longitudinal trajectories with linear mixed-effects models.

Results

Symptomatic females with genetic FTD had lower frontal cortical thickness than males, and the C9orf72 subgroup

SUBMITTER: Garcia Castro J 

PROVIDER: S-EPMC12022895 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature