Synthesis, Microbiology, and Biophysical Characterization of Mutanofactins from the Human Oral Microbiome.

ABSTRACT: Mutanofactins are a family of natural products produced by Streptococcus mutans from the human oral microbiome. We report a unified approach to all mutanofactins by developing a total synthesis amenable to diversification. The key to success for the most complex members, mutanofactins 607 and 697, was an acyl ketene based strategy. Access to the family enabled comprehensive biological profiling, where we demonstrate that all mutanofactins are biofilm promoting in Streptococcus mutans. Experiments were extended to other inhabitants of the oral microbiome for the first time: Streptococcus gordonii and Streptococcus oralis, two early colonizers, were similarly affected with mutanofactins being biofilm promoting. Conversely, Veillonella dispar and Fusobact

SUBMITTER: Luthy L 

PROVIDER: S-EPMC12022917 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature