Combating Concomitant Bacterial and Fungal Infections via Codelivery of Nitric Oxide and Fluconazole.

ABSTRACT: Device-associated infections are a major challenge for healthcare and cause patient morbidity and mortality as well as pose a significant economic burden. Infection-causing bacteria and fungi are equally notorious and responsible for biofilm formation and the development of antibiotic and antifungal-resistant strains. Biomaterials resisting bacterial and fungal adhesion can address device-associated infections more safely and efficiently than conventional systemic antibiotic therapies. Herein, we present a combination of potent antibacterial nitric oxide (NO) with antifungal fluconazole codelivery system from a polymeric matrix to combat bacterial and fungal infections simultaneously. The NO donor S-nitroso-N-acetyl-penicillamine (SNAP)-blended low-water-uptake polycarbonate

SUBMITTER: Pandey R 

PROVIDER: S-EPMC12022954 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature