Backbone 1H, 13C, and 15N chemical shift assignments for human SERF2.

ABSTRACT: Human small EDRK-rich factor protein SERF2 is a cellular driver of protein amyloid formation, a process that has been linked to neurodegenerative diseases including Alzheimer's and Parkinson's disease. SERF2 is a 59 amino acid protein, highly charged, and well conserved whose structure and physiological function is unclear. SERF family proteins including human SERF2 have shown a tendency to form fuzzy complexes with misfolded proteins such as α-Synuclein which has been linked to Parkinson's disease. SERF family proteins have been recently identified to bind nucleic acids, but the binding mechanism(s) remain enigmatic. Here, using multidimensional solution NMR, we report the ¹H, ¹⁵N, and ¹³C chemical shift assignments (~ 86% of backbone resonance assignments

SUBMITTER: Sahoo BR 

PROVIDER: S-EPMC12022958 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature