Evidence for a Unifying Ni^I/Ni^III Mechanism in Light-Mediated Cross-Coupling Catalysis.

ABSTRACT: Advances in nickel catalysis have significantly broadened the synthetic chemists' toolbox, particularly through methodologies leveraging paramagnetic nickel species via photoredox catalysis or electrochemistry. Key to these reactions is the oxidation state modulation of nickel via single-electron transfer events. Recent mechanistic studies indicate that C(sp²)-heteroatom bond formations proceed through Ni^I/Ni^III cycles. Related C(sp²)-C(sp³) cross-couplings operate via the photocatalytic generation of C-centered radicals and a catalytic cycle that involves Ni⁰, Ni^I, and Ni^III species. Here, we show that light-mediated nickel-catalyzed C(sp²)-C(sp³) bond formations can be carried ou

SUBMITTER: Anghileri L 

PROVIDER: S-EPMC12022987 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature