Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages.

ABSTRACT: Both tissue-resident macrophages and monocytes recruited from the bone marrow that transform into tissue-resident cells play critical roles in mediating homeostasis as well as in the pathology of inflammatory diseases. Inorganic arsenic (iAs) is the most common drinking water contaminant worldwide and represents a major public health concern. There are numerous diseases caused by iAs exposure in which macrophages are involved, including cardiovascular disease, cancer, and increased risk of (respiratory) infectious diseases. Notably, prenatal iAs exposure is also associated with negative birth outcomes and developmental immunotoxicity (DIT) contributing to long-term adverse outcomes of these immune-related diseases. Therefore, understanding the effects of iAs exposure on macrophages, partic

SUBMITTER: Illingworth EJ 

PROVIDER: S-EPMC12023008 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature