Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003-2017.

ABSTRACT:

Background

Systemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk.

Methods

In this cross-sectional study of NHANES 2003-2017, data from 19,856 participants were analyzed, including 652 participants with HF and 19,204 without HF. Participants were categorized into quartiles based on IBI levels (Q1-Q4). The risk of HF across these quartiles was assessed with adjustment for potential confounders and restricted cubic spline analyses were used to evaluate dose-response relationships.

Results

Our results show that participants with HF have higher IBI levels compared to those without HF (2.66 ± 0.27 vs. 1.05 ± 0.03, p < 0.001). The prevalence of HF increase

SUBMITTER: Yun LX 

PROVIDER: S-EPMC12023371 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature