Comparing the impact of cumulative insulin resistance surrogates exposure on stroke: optimizing prevention strategies.

ABSTRACT:

Background

Insulin resistance (IR) plays a major role in increasing the risk of stroke. The objective of this research is to systematically evaluate and compare the impact of cumulative exposure over time to four commonly used IR surrogates-triglyceride-glucose (CumTyG) index, metabolic score for IR (CumMetS-IR), estimated glucose disposal rate (CumeGDR) and triglyceride to high-density lipoprotein cholesterol (CumTG/HDL-C) ratio-on stroke risk, providing insights for optimizing monitoring strategies for primary stroke prevention.

Methods

The study population was sourced from the China Health and Retirement Longitudinal Study (CHARLS2011-2018). Cumulative exposure to IR (CumIR) surrogates was calculated as the mean value of IR surrogates measured in the first and third waves

SUBMITTER: Hong D 

PROVIDER: S-EPMC12023373 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature