Psychopharmacology in children with genetic disorders of epigenetic and chromatin regulation.

ABSTRACT:

Objective

Hundreds of rare genetic variants associated with autism or intellectual disability have been identified, and many impact genes known to have a primary epigenetic/chromatin regulatory function. The objective of this study was to examine and compare behavioural profiles and longitudinal psychotropic treatment patterns in children with epigenetic/chromatin variants, other rare variants impacting neurodevelopment, or no known genetic condition.

Methods

Using electronic medical records from a pediatric psychopharmacology program for children with autism or intellectual disability, we compared clinical characteristics, longitudinal psychotropic medication profiles and side effects between those with and without a rare genetic variant, and by variant subtype [epigenetic/

SUBMITTER: Lenz S 

PROVIDER: S-EPMC12023381 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature