Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration.

ABSTRACT:

Background

Dyslipidemia has been proved to play a pivotal role in biological aging. Atherogenic Index of Plasma (AIP), derived from serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), is an effective biomarker of dyslipidemia. However, whether AIP can be used as an indicator of biological aging remains unclear. This study aims to investigate the relationship between AIP and biological aging in the US adult population.

Methods

4,471 American adults with age over 20 years from the National Health and Nutrition Examination Survey (NHANES) database were included in this study. Biological aging was assessed by phenotypic age acceleration (PhenoAgeAccel). Multivariable linear regression models, subgroup analyses and interaction tests were employed to explore

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12023499 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature