Genome-wide characterization and expression analysis of WRKY family genes in the biosynthesis of triptolide in Tripterygium wilfordii.

ABSTRACT:

Background

WRKY transcription factors play a vital role in regulating plant growth, development, and secondary metabolism. Tripterygium wilfordii is a medicinal plant that has been widely utilized in rheumatoid arthritis therapy; it contains triptolide, a prominent bioactive constituent exhibiting potent anti-inflammatory and anti-tumor properties. However, the mechanism underlying the regulatory effects of WRKY on triptolide biosynthesis is poorly understood.

Results

In this study, 95 TwWRKY genes were identified in the T. wilfordii genome, which were divided into three groups. Phylogenetic analysis indicated that the TwWRKY were conservative relative to other plants. Collinearity analysis revealed that gene duplications played a crucial role in the evolution of this gene f

SUBMITTER: Tang L 

PROVIDER: S-EPMC12023552 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature