Evidence supporting the role of hypertension in the onset of migraine.

ABSTRACT:

Background

The association between hypertension and migraine remains unclear.

Objective

The aim of this study employ multi-layered evidence chain that revealed the association between hypertension and migraine.

Methods

We first strictly included data from the NHANES 1999-2004 population and applied logistic regression, subgroup analysis and RCS to assess the correlation between hypertension, SBP, DBP and migraine. Meanwhile, LDSC and Mendelian randomization were conducted based on the GWAS to determine the causal relationship between hypertension and migraine. Inverse-variance weighted (IVW) was used as the primary method. Sensitivity analysis and Colocalization analysis were performed to confirm the robustness of the results. LDSC validated the genetic correlation be

SUBMITTER: Xiao G 

PROVIDER: S-EPMC12023583 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature