Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO₂ and carbon black.

ABSTRACT:

Background

Chronic inhalation of titanium dioxide or carbon black can lead, at high exposure, to lung overload, and can induce chronic inflammation and lung cancer in rats. Whether this rat adverse response is predictive for humans has been questioned for more than 40 years. Currently, these particles are conservatively considered as possible human carcinogens.

Objective

To clarify the mechanisms of the adverse rat response to lung overload and its human relevance.

Methods

Primary rat and human alveolar macrophages were exposed in vitro to control, non-overload or overload doses of titanium dioxide (P25) or carbon black (Printex 90) particles, and their activation profile was examined by untargeted transcriptomics.

Results

Rat macrophages were largely the most

SUBMITTER: Perez L 

PROVIDER: S-EPMC12023592 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature