Nano-zinc oxide (nZnO) targets the AMPK-ULK1 pathway to promote bone regeneration.

ABSTRACT:

Background

Nano-zinc oxide (nZnO) has attracted significant attention in bone tissue engineering due to its antibacterial properties, anti-inflammatory effects, biocompatibility, and chemical stability. Although numerous studies have demonstrated the enhancement of osteogenic differentiation by nZnO-modified tissue engineering materials, the underlying mechanisms remain poorly characterized.

Methods

This study aimed to identify the molecular mechanisms how nZnO promoted osteogenic differentiation and bone regeneration using transcriptome analysis, drug intervention, and shRNA knockdown techniques, etc. First, the study evaluated the in vivo effects of gelatin methacryloyl (GelMA) containing nZnO on bone regeneration using a mouse calvarial defect model. The impact of nZnO ex

SUBMITTER: Chen X 

PROVIDER: S-EPMC12023698 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature