Long-term remission of Hailey-Hailey disease by Er:YAG ablative laser therapy.

ABSTRACT:

Background

Hailey-Hailey disease (HHD) is a rare genetic therapy-resistant blistering disease with great disease burden. Treatment is currently focused on symptomatic relief. Er:YAG ablative laser therapy is a therapeutic modality with promising results, though evidence is currently scarce.

Objective

To analyse the effect of Er:YAG ablative laser therapy on clinical remission of erosive plaques in HHD and on patient's quality of life (QoL).

Methods

In this observational study eight patients were included and 77 erosive plaques were treated once only by Er:YAG laser and assessed for clinical remission. QoL was evaluated by obtaining Skindex-29 and DLQI questionnaires before laser therapy, 6 weeks and 3 years after laser therapy. Skin biopsies were taken to evaluate the

SUBMITTER: Debeuf MPH 

PROVIDER: S-EPMC12023705 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature