Environmental and dietary factors associated with urinary OH-PAHs in mid-pregnancy in a large multi-site study.

ABSTRACT:

Background

PAH exposure is associated with adverse health outcomes, but exposure sources in pregnancy are not well-understood.

Objectives

We examined associations between urinary OH-PAHs during pregnancy and environmental tobacco smoke (ETS) and short-term ambient air pollution exposure. Participants included 1603 pregnant non-smokers in three cohorts from 7 sites across the USA. We also examined associations with intake of foods typically high in PAHs in one cohort with dietary assessment data (n = 801).

Methods

Urinary OH-PAHs were measured using LC-MS/MS; urinary cotinine was measured using SPE/UPLC-MS/MS. To accommodate different detection limits by cohort, ETS exposure was represented by modified cotinine quartiles; these combined concentrations below the highest

SUBMITTER: Riederer AM 

PROVIDER: S-EPMC12023758 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature