Characterization of the novel cross-genus phage vB_SmaS_QH3 and evaluation of its antibacterial efficacy against <i>Stenotrophomonas maltophilia</i>.

ABSTRACT:

Background

Bacteriophages, which are natural bacterial predators, demonstrate potential as safe and effective biological control agents against drug-resistant infections. This study aims to characterize the biological properties of the novel lytic phage vB_SmaS_QH3 and comprehensively evaluate its efficacy in preventing and controlling clinically multidrug resistance Stenotrophomonas maltophilia infections using both in vivo and in vitro models.

Methods

The phage was isolated from hospital sewage using the multidrug resistant S. maltophilia no. 3738 as the host. Transmission electron microscopy (TEM) was used to observe phage morphology, and the host range was determined via spot assays. Proliferation kinetics, including multiplicity of infection

SUBMITTER: Cheng P 

PROVIDER: S-EPMC12023781 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature