Macrophage ATG16L1 promotes liver regeneration after partial hepatectomy.

ABSTRACT:

Background & aims

Autophagy plays an important role in liver regeneration. However, most studies are limited to hepatocytes, and the function and mechanism of macrophage autophagy in liver regeneration remain unclear. This study investigated the role of the essential autophagy gene encoding autophagy-related 16-like 1 (ATG16L1), which regulates the macrophage phenotype in liver regeneration.

Methods

We generated FloxP-Atg16l1 (Atg16l1 ^FL/FL ), Lyz2-Cre Atg16l1 knockout (KO) (Atg16l1 ^M-KO ), and myeloid-specific Atg16l1-overexpression-knock-in (Atg16l1 ^OE ) mice. These mice were subjected to 70% partial hepatectomy to demonstrate the role of ATG16L1 in macrophages during liv

SUBMITTER: Zhan X 

PROVIDER: S-EPMC12023798 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature