Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound.

ABSTRACT: Hydrogels are soft, tissue-like materials that have great potential as wound dressings. However, most hydrogels are unsatisfactory in achieving whole-layer regeneration of diabetic wounds due to the complex pathological microenvironment and irregular wound shapes. Here, a glucose-responsive and self-adaptive phenylboronic acid (PBA) hydrogel solubilized strong antioxidant flavonoids (Gel-Flavonoids) is developed via dynamic borate bonds. The Gel-Flavonoids system can spontaneously confirm to the irregular wound shape and release flavonoids in a high-glucose microenvironment to effectively eliminate reactive oxygen species (ROS). The optimized Gel-Flavonoids demonstrate remarkable efficacy in inhibiting inflammation and activating fibroblasts and endothelial cells through CD36-activated lip

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC12023815 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature