Injectable 2D-MoS₂-integrated Bioadhesive Hydrogel as Photothermal-Derived and Drug-Delivery Implant for Colorectal Cancer Therapy.

ABSTRACT: Photothermal therapy (PTT) combined with chemotherapy using hydrogel as a delivery platform is considered a promising strategy for the treatment of advanced colorectal cancer (CRC). However, maintaining the stability of photo-absorbing agents (PTA) in the hydrogel and ensuring that the hydrogel remains anchored to the tumor tissue presents significant challenges. Herein, this work introduces an injectable 2D molybdenum disulfide (2D-MoS₂)-integrated adhesive hydrogel, specifically N-(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitro-sophenoxy) butanamide-linked sodium alginate-MoS₂-5-fluorouracil (AlgNB/MoS₂/5-FU). This hydrogel functions as a near-infrared light (NIR)-triggered photothermal and drug-delivery implant for CRC treatment. The MoS₂

SUBMITTER: Long X 

PROVIDER: S-EPMC12023830 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature