Living Microalgae-Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy.

ABSTRACT: The combination of Ca²⁺ overload and reactive oxygen species (ROS) production for cancer therapy offers a superior solution to the lack of specificity in traditional antitumor strategies. However, current therapeutic platforms for this strategy are primarily based on non-targeting nanomaterials, leading to undesirable off-target side effects. Additionally, resistance to ROS and apoptosis induced by the hypoxic tumor microenvironment (TME) further limits therapeutic efficiency. Herein, a magnetic microrobot based on living Spirulina Platensis (SP), which is coated with a double layer of Fe₃O₄ nanoparticles (NPs) and CaCO₃ NPs. The microrobots can accumulate in tumor regions under magnetic attraction, which produces a high-Ca²⁺ environme

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12023837 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature