Encoding-related hippocampus connectivity for scenes, faces, and words: Healthy people compared to people with temporal and frontal lobe epilepsy.

ABSTRACT: Interactions of the hippocampus with other brain structures are supposed to support memory formation but knowledge is limited regarding hippocampal task-based functional connectivity (FC) during encoding in both healthy people and people with epilepsy, who frequently have impaired memory. We compared absolute [FC(encoding)] and relative FC (isolating task-specific FC [FC(encoding)-FC(baseline)]) of the anterior hippocampus in 30 controls, 56 mesial temporal (mTLE, 26 right) and 24 frontal lobe epilepsy (FLE) patients using a memory fMRI-task of encoding scenes, faces and words. In controls, absolute hippocampus FC comprised regions typically active in memory fMRI-tasks and the default mode network (DMN): For faces and scenes, FC was pronounced to temporo-occipital areas, whereas for words

SUBMITTER: Doll A 

PROVIDER: S-EPMC12023899 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature