Trace Element Concentrations in Degenerative Lumbar Spine Tissues: Insights into Oxidative Stress.

ABSTRACT: Degenerative changes are characterized by the formation of vertebral osteophytes, the hypertrophy of facet joints, and narrowing of the intervertebral space. This study aimed to investigate the concentrations of trace elements (Al, As, Se, Zn, Fe, Mo, Cu) in spinal tissues (intervertebral discs, muscle, and bone) of patients with degenerative lumbar spine disease (DLSD) and their potential associations with the disease. The research involved 13 patients undergoing surgery for symptomatic degenerative spine disease. The trace element concentrations were analyzed using chemical and radiographic assessments, with a statistical analysis performed through a Mann-Whitney U-test, Spearman's rank correlation test, principal component analysis (PCA), and canonical discriminant analysis (CDA). The r

SUBMITTER: Dabrowski M 

PROVIDER: S-EPMC12024161 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature