Distribution of Antimicrobial Resistance and Biofilm Production Genes in the Genomic Sequences of <i>S. aureus</i>: A Global In Silico Analysis.

ABSTRACT: Background:Staphylococcus aureus constitutes a significant public health threat due to its exceptional adaptability, antimicrobial resistance (AMR), and capacity to form biofilms, all of which facilitate its persistence in clinical and environmental settings. Methods: This study undertook an extensive in silico analysis of 44,069 S. aureus genomic sequences acquired from the NCBI database to assess the global distribution of biofilm-associated and resistance-associated genes. The genomes were categorized into human clinical and environmental groups, with clinical samples representing a predominant 96%. Results: The analysis revealed notable regional discrepancies in sequencing efforts, with Europe and North America contributing 76% of the genomes. Key fin

SUBMITTER: Silva-de-Jesus AC 

PROVIDER: S-EPMC12024283 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature