Anticancer Potential, Phenolic Profile, and Antioxidant Properties of <i>Synsepalum dulcificum</i> (Miracle Berry) in Colorectal Tumor Cell Lines.

ABSTRACT: Polyphenols, recognized for their antioxidant capacity, have shown potential in improving the response treatment of various diseases, including cancer. In this context, polyphenols have the ability to induce cytotoxicity in tumor cells, making them possible complementary agents to current treatments. The present study aims to evaluate the effect of the aqueous extract of Synsepalum dulcificum, using the commercial product DMB^®, on the proliferation of colorectal tumor cells. An aqueous extract of DMB^® was obtained, and 12 compounds were identified through high-performance liquid chromatography (HPLC), with protocatechuic acid, gallic acid, and catechin being the most prominent. Regarding cytotoxicity, the extracts reduced cell viability in the DLD-1, HT29, SW48

SUBMITTER: Quiroz-Troncoso J 

PROVIDER: S-EPMC12024304 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature