Virtual Therapy Planning of Aortic Valve Replacement for Preventing Patient-Prosthesis Mismatch.

ABSTRACT:

Background

Recent studies suggest that any degree of patient-prosthesis mismatch (PPM) increases morbidity and mortality after surgical aortic valve replacement (SAVR). We used computational fluid dynamics simulations to test the influence of prosthesis size and physical activity after SAVR.

Methods

In 10 patients with aortic valve stenosis, virtual SAVR was performed. Left ventricular outflow tract stroke volume and flow direction information (4D Flow) were used, and an increase in stroke volume of 25% was chosen for simulating physical activity. Pressure gradients (DP max) across the aortic valve and blood flow profiles in the ascending aorta were calculated and predicted for three different valve sizes at rest and under stress in every patient.

Results

Gradients ac

SUBMITTER: Schafstedde M 

PROVIDER: S-EPMC12024315 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature