Persistence of Colistin Resistance and <i>mcr-1.1</i>-Positive <i>E. coli</i> in Poultry Despite Colistin Ban in Japan.

ABSTRACT: Colistin, a polymyxin antibiotic used as a last-resort treatment for serious infections, exhibits efficacy against multidrug-resistant organisms. Colistin-resistant bacteria limit the treatment options and increase the risk of untreatable infections. In this study, we investigated various antimicrobial-resistant Escherichia coli strains isolated from broiler cecal feces. In the primary screening using CHROMagar C3GR and ESBL, 147 E. coli isolates were obtained from 231 broiler cecal samples at five domestic poultry farms in Japan in 2024. Of the 147 isolates tested for antimicrobial susceptibility, 20 (13.6%) showed resistance to colistin. Moreover, whole-genome sequencing detected the colistin resistance gene, mcr-1.1 (phosphoethanolamine transferase), in the colistin

SUBMITTER: Kawano K 

PROVIDER: S-EPMC12024320 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature