Redox Mechanisms Driving Skin Fibroblast-to-Myofibroblast Differentiation.

ABSTRACT: Transforming Growth Factor-Beta 1 (TGF-β1) plays a pivotal role in the differentiation of fibroblasts into myofibroblasts, which is a critical process in tissue repair, fibrosis, and wound healing. Upon exposure to TGF-β1, fibroblasts acquire a contractile phenotype and secrete collagen and extracellular matrix components. Numerous studies have identified hydrogen peroxide (H₂O₂) as a key downstream effector of TGF-β1 in this pathway. H₂O₂ functions as a signalling molecule, regulating various cellular processes mostly through post-translational redox modifications of cysteine thiol groups of specific proteins. In this study, we used primary human skin fibroblast cultures to investigate the oxidative mechanisms triggered by TGF-β1. We analyzed th

SUBMITTER: Aminzadehanboohi M 

PROVIDER: S-EPMC12024386 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature