Decoding biomaterial-associated molecular patterns (BAMPs): influential players in bone graft-related foreign body reactions.

ABSTRACT: Bone grafts frequently induce immune-mediated foreign body reactions (FBR), which hinder their clinical performance and result in failure. Understanding biomaterial-associated molecular patterns (BAMPs), including physicochemical properties of biomaterial, adsorbed serum proteins, and danger signals, is crucial for improving bone graft outcomes. Recent studies have investigated the role of BAMPs in the induction and maintenance of FBR, thereby advancing the understanding of FBR kinetics, triggers, stages, and key contributors. This review outlines the stages of FBR, the components of BAMPs, and their roles in immune activation. It also discusses various bone grafting biomaterials, their physicochemical properties influencing protein adsorption and macrophage modulation, and the key mechani

SUBMITTER: Brigi C 

PROVIDER: S-EPMC12024449 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature