ADVANCE: a biomedical informatics approach to investigate acute kidney injury in infants.

ABSTRACT:

Background

Acute kidney injury (AKI) occurs in up to half of infants admitted to the neonatal intensive care unit (NICU) and is associated with increased risks of death and more days of mechanical ventilation, hospitalization, and vasopressor drug support. Our objective was to build a granular relational database to study the impact that AKI has on infants admitted to Level-IV NICUs.

Methods

A relational database was created by linking data from the Children's Hospitals Neonatal Database with AKI-focused data from electronic health records from 9 centers.

Results

The current cohort consists of 24,870 infants with a median (IQR) gestational age of birth of 37 weeks (32 weeks, 39 weeks), and a median birth weight of 2.720 kg (1.750 kg, 3.310 kg). There was a male predom

SUBMITTER: Rumpel JA 

PROVIDER: S-EPMC12024515 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature