Synthesis and Evaluation of Isosteviol Derivatives: Promising Anticancer Therapies for Colon Cancer.

ABSTRACT: Background: Isosteviol, a tetracyclic diterpenoid with a beyerene-type skeleton, exhibited wide pharmacological activities and an inhibitory impact on tumor proliferation in colon cancer; Methods: 22 isosteviol derivatives were synthesized by modifying the C-16 and C-19 position of isosteviol, and then the inhibitory activities of derivatives 2-22 were evaluated by CCK8 method. Next, the structure-activity relationships (SARs) of these isosteviol derivatives in HCT116 cells were discussed in detail. Network pharmacology was employed to predict and analyze the targets of isosteviol in the treatment of colon cancer; Results: The results indicated derivative 8 possessed stronger inhibitory activity against HCT116 and HepG2 cells (IC₅₀ = 6.2

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12024579 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature