Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against <i>Glaesserella parasuis</i> Challenge.

ABSTRACT: Glaesserella parasuis (G. parasuis) causes Glässer's disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects. In this study, we investigated the effects of baicalin, amoxicillin, and probenecid on blood biochemical parameters, routine blood indicators, survival rate, bacterial burden, and pathological tissue damage in G. parasuis-challenged mice. Treatment with baicalin, amoxicillin, and probenecid significantly modified the blood biochemical parameters and routine blood test indicators, increased the survival rate, attenuated the bacterial burden, and alleviated pathological tissue damage in G. parasuis-challenged mice. Trea

SUBMITTER: Li J 

PROVIDER: S-EPMC12024593 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature