Causal Links Between Corneal Biomechanics and Myopia: Evidence from Bidirectional Mendelian Randomization in the UK Biobank.

ABSTRACT:

Background

Myopia is a leading cause of visual impairment worldwide, and accumulating evidence suggests that biomechanics may be closely linked to its development. Understanding this relationship may help clarify the underlying mechanisms of myopia and guide treatment strategies. The aim of the study is to investigate the causal relationship between myopia and corneal biomechanics using the UK Biobank (UKB) database.

Methods

Data from 11,064 eyes in the UKB, including refraction results and Ocular Response Analyzer (ORA) measurements, were analyzed. Eyes were categorized by spherical equivalent (SE) into emmetropia, mild myopia, moderate myopia, and high myopia. One-way ANOVA assessed differences in corneal biomechanical parameters across the varying myopia groups, while Qua

SUBMITTER: Li X 

PROVIDER: S-EPMC12024697 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature