Gene Polymorphisms of Parkinson's Disease Risk Locus and Idiopathic REM Sleep Behavior Disorder.

ABSTRACT: Background/Objectives: Genetic factors play an important role in idiopathic rapid eye movement sleep behavior disorder (iRBD) but have not been fully studied. This study aimed to analyze the Parkinson's disease (PD)-related genetic loci in iRBD in the southern Chinese population. Methods: In this study, we recruited 292 individuals with PD, 62 with iRBD, and 189 healthy controls (HC). Candidate genes were identified primarily from the Parkinson's Progression Markers Initiative (PPMI) database. Genotypic and allele frequency analyses were conducted to compare the distribution across HC, iRBD, and PD groups. The effects of significant single-nucleotide polymorphisms (SNPs) on gene expression were examined. Clinical manifestations associated with different genotypes were also an

SUBMITTER: Zhong M 

PROVIDER: S-EPMC12024845 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature