A pH-Responsive Dendritic-DNA-Based Nanohydrogel for Dual Drug Delivery.

ABSTRACT: The rational design of multifunctional drug delivery systems capable of achieving precise drug release remains a huge challenge. Herein, we designed a stimuli-responsive dendritic-DNA-based nanohydrogel as a nanocarrier to achieve the co-delivery of doxorubicin and HMGN5 mRNA-targeting antisense oligonucleotides, thus achieving dual therapeutic effects. The nanocarrier, constructed from dendritic DNA with three crosslinking branches and one loading branch, formed biocompatible and programmable DNA nanohydrogels. The C-rich sequences in the crosslinking branches conferred pH sensitivity, while the loading strand enabled efficient incorporation of a shielding DNA/ASO complex. DOX encapsulation yielded a chemo-gene co-delivery platform. Upon cellular uptake by cancer cells, the nanocar

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12024947 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature