Biphasic Effects of Blue Light Irradiation on Different Drug-Resistant Bacterium and Exploration of Its Mechanism.

ABSTRACT: Background: Antimicrobial resistance is a problem that threatens the entire world population. Blue light irradiation (BLI) is a novel technology with a bactericidal effect. However, it has only been employed in experimental and preclinical trials. Methods: We employed BLI on four kinds of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, and Escherichia coli) and six kinds of artificial implants utilizing a BioLight LED lamp and MEDILIGHT at a 453 nm wavelength. Results: The results showed that the antibacterial effect of BLI enhanced with time and dosage. Irradiation of 165.6 J/cm² corresponding to 120 min of constant mode irradiation, resulted in a significant reduction in

SUBMITTER: Mu Y 

PROVIDER: S-EPMC12024981 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature