SAA1 Protein: A Potential Biomarker for Acute Myeloid Leukemia.

ABSTRACT: Background/Objectives: Despite its heterogeneity and diagnostic challenges, acute myeloid leukemia (AML) originates from stem cell transformation and alterations in the hematopoietic niche (HN) could be related to leukemic transformation. Therefore, the aim of this study was to evaluate the protein profile of HN from AML patients and compare it with the profile of healthy donors (HDs). Methods: A proteomic analysis was conducted to identify differentially expressed (DE) proteins in BM plasma from AML patients and HD. In silico analysis was performed to identify biological processes and signaling pathways involved. Additionally, ELISA confirmed the expression of the DE protein of interest in BM plasma samples. Results: Proteomic analysis revealed alterations in the plas

SUBMITTER: Azevedo PL 

PROVIDER: S-EPMC12024993 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature