Phlorizin Protects Against Oxidative Stress and Inflammation in Age-Related Macular Degeneration Model.

ABSTRACT:

Background

Sweet Tea (Lithocarpus polystachyus Rehd.), a traditional ethnobotanical medicine, contains phlorizin, a dihydrochalcone compound with antioxidative and anti-inflammatory properties. Given the critical role of oxidative stress and inflammation in age-related macular degeneration (AMD), this study tested the hypothesis that phlorizin mitigates oxidative damage and inflammation in AMD models, thereby offering therapeutic potential.

Materials and methods

Adult retinal pigmented epithelial cells (ARPE-19) were pre-treated with phlorizin (0.01-0.1 μM) and subjected to oxidative stress induced by ultraviolet A (UVA) radiation or sodium iodate (NaIO₃). Cell viability, reactive oxygen species (ROS) production, MAPK/NF-κB signaling, and the level of pro-inflamma

SUBMITTER: Liao ZY 

PROVIDER: S-EPMC12025036 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature