Amyloid-β positivity is less prevalent in cognitively unimpaired <i>KLOTHO</i> KL-VS heterozygotes.

ABSTRACT:

Background

Klotho, encoded by the KLOTHO gene, is an anti-aging and neuroprotective protein. KLOTHO KL-VS heterozygosity (KL-VS_HET) is hypothesized to be protective against the accumulation of Alzheimer's disease (AD) neuropathological hallmarks (amyloid-β (Aβ) and tau).

Objective

We examine whether being positive for Aβ (A+) or tau (T+), or A/T joint status [positive for Aβ (A + T-), tau (A-T+), both (A + T+) or neither (A-T-)] vary by KL-VS and whether serum klotho protein levels vary based on A+, T+, or A/T status in a cohort enriched for AD risk.

Methods

The sample consisted of 704 cognitively unimpaired, late middle-aged, and older adults; Mean_Age(SD) = 64.9(8.3). Serum klotho was available for a sub-sample of 396 participants;

SUBMITTER: Cook N 

PROVIDER: S-EPMC12025201 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature