Early Results of an Infant Model of Orthotopic Cardiac Xenotransplantation.

ABSTRACT:

Background

Genetically engineered porcine hearts may have an application for infants in need of a bridge to cardiac allotransplantation. The current animal model that resulted in 2 human applications has been validated in adult non-human primates only. We sought to create an infant animal model of life sustaining cardiac xenotransplantation to understand limitations specific to this age group.

Methods

We performed 11 orthotopic cardiac xenotransplants from genetically modified infantile pigs into size-matched baboons (Papio spp). Porcine grafts were preserved using a modified Del Nido solution. Protocolized post-operative care and outcomes were tracked with invasive monitoring, echocardiogram, and serial chemistries (including a 7-cytokine panel).

Results

Mean ischemi

SUBMITTER: Mitchell CB 

PROVIDER: S-EPMC12025259 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature