Oxidative Stress in Huntington's Disease.

ABSTRACT: Although the pathogenesis of the neurodegenerative phenomena of Huntington's disease (HD) is not well known, in the last 30 years, numerous data have been published that suggest a possible role of oxidative stress. The majority of studies regarding this issue were performed in different experimental models of this disease (neurotoxic models such as intraperitoneal injection of 3-nitropropionic acid or intrastriatal injection of quinolinic acid, transgenic animal models for HD, and cell cultures) and, less frequently, in samples of brain tissue, plasma/serum, blood cells, and other tissues from patients with a genetic-molecular diagnosis of presymptomatic and symptomatic HD compared to healthy controls. In this narrative review, we have summarized the data from the main studies in which oxi

SUBMITTER: Jimenez-Jimenez FJ 

PROVIDER: S-EPMC12025275 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature