LncRNA <i>EGOT</i> Is the Marker of HPV Infection and a Prognostic Factor for HNSCC Patients.

ABSTRACT: Background: High-risk human papillomavirus (HPV) contributes to oropharyngeal cancers through mechanisms involving the deregulation of host cell functions by oncoproteins E6 and E7. Changes in the epigenome, particularly involving long non-coding RNAs (lncRNAs), are crucial for understanding HPV-related carcinogenesis. Methods: This study aimed to analyze the expression levels of lncRNAs in HPV-related head and neck squamous cell carcinoma (HNSCC) to determine their biological and clinical significance, addressing the current gap in clinically validated biomarkers for early screening and therapeutic interventions. Results: The study highlights the significant overexpression of the EGOT gene in HPV-positive HNSCC samples, suggesting its potential as a marker to d

SUBMITTER: Kolenda T 

PROVIDER: S-EPMC12025276 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature